Anti-convulsant Hypersensitivity Syndrome with Predominant Liver Involvement

Abstract

Anticonvulsant hypersensitivity syndrome (AHS) is a rare but potentially life threatening syndrome that develops in genetically susceptible individuals following exposure to aromatic antiepileptic drugs (AED’s) like phenytoin. It is characterized by fever, rash and internal organ involvement. AHS should be recognized at the earliest because continuation of the culprit drug can lead to fatal outcome. We present severe phenytoin hypersensitivity syndrome with predominant hepatic involvement that improved with drug withdrawal and other supportive treatment. JMS 2011;14(1):22-24