Steroid induced avascular necrosis of femoral head in ALL patients-two case reports

Abstract

Avascular necrosis of bone or Osteonecrosis incidence has been increasing in a larger number of surviving ALL patients, especially in adolescents and young adults [1]. Osteonecrosis and decreased bone mineral density(BMD) are well-known side effects of corticosteroids and avascular necrosis has been reported as one of the leading causes of treatment related morbidity in ALL survivors [2]. Symptomatic avascular necrosis has been reported to occur in up to 20% of children and adolescents with ALL [3]. We are reporting two cases of ALL patients who have been treated with steroid and chemotherapy and developed avascular necrosis of bilateral femoral heads.