SPECTRUM OF LIVER DISORDERS IN PREGNANCY

Abstract

Background: Liver disorders comprise 3% of all pregnancy complications. All liver disorders,pregnancy-specific,pregnancy-related and pregnancy unrelated disorders have both maternal and fetal effects. The present study was conducted to study the spectrum of liver disorders in pregnancy.

Objective: To study the spectrum of liver disorders in pregnancy. To study the effect of liver disorder on pregnancy outcome. To formulate a plan to prevent maternal morbidity and mortality in patients with liver disorders in pregnancy.

Study-Design: Case-Control study

Material & Methods: All pregnant patients with clinical and biochemical evidence of liver dysfunction were taken as cases. Pregnant women with normal liver function tests were taken as controls. All patients were followed during pregnancy and postpartum. The maternal and fetal outcome was studied

Results: A total of 140 patients were included- 70 cases and 70 controls. Pregnancy specific liver disorders were seen in 81.4%, among which Intrahepatic cholestasis of pregnancy was most frequent[41.4%].PPH and oligohydroamnios were most frequent among cases with a p value of 0.034 and 0.035 respectively. Similarly preterm birth, RDS and perinatal asphyxia was more common in cases with a p-value of 0.011,0.001 and 0.005 respectively

 Conclusions: Study concludes that liver disorders in pregnancy have adverse maternal and fetal complications