HYPO-FRACTIONATED RE-IRRADIATION BY 3DCRT/IMRT IN RECURRENT ANAPLASTIC ASTROCYTOMA & GLIOBLASTOMA MULTIFORME AN OBSERVATIONAL STUDY

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Abstract

Background: High-grade gliomas (HGGs) are the most common malignant primary brain tumors in adults and are associated with poor prognosis.

OBJECTIVES:

1. To assess progression-free survival and overall survival in all patients diagnosed with recurrent High-grade Gliomas.2. To assess Local tumor control Rate (Response Rate) .3. To assess the effect on the quality of life (QOL) .4. To assess Treatment-Related Toxicities.

MATERIAL & METHODS: The study was conducted in the Department of Radiation Oncology SKIMS, Soura Srinagar; enrollment of cases was taken from September 2017 to July 2019. All patients eligible for this study were enrolled. All patients were treated with Hypofractionated protocol by 3DCRT/IMRT techniques, dose, and fractions intended (20Gy in five fractions) using LINAC Accelerator.

RESULTS (Truncated): The present study was conducted between September 2017 to July 2019 in the department of radiation oncology and included a total of 22 patients. Despite the use of more effective multimodality treatment in High-Grade Glioma, the outcome of patients affected by this disease is still dismal & the recurrence/residual rate is very high. the median overall survival rate was 4.2 months (3-23 months) , and median progression-free survival was 2.8 months (Range 1- 13 months) . Our longest follow-up was of 23 months, while the shortest one was of 3 months.

CONCLUSION: reirradiation is one of the treatment options for recurrent high-grade gliomas, and conformal (IMRT) can be an effective treatment modality for recurrent high-grade brain tumors with only mild side effects. Although survival is better in patients with good performance status and young age.